Introduction and basic principles/Choice of animals and their husbandry/Understanding and controlling variability/The analysis of variance/Completely randomised (CR) single factor design/Factorial experiments/Randomised block (RB) designs/Split plots, Latin squares, covariance and other techniques./Counts and proportions/Regression and correlation/The determination of sample size/Seventeen steps in designing a randomised controlled animal experiment/Concluding remarks/Appendix 1. R and R Commander/Appendix 2. Further reading/Appendix 3. Learning outcomes for module 10 and part (ii) of Module 11 of the Education and training framework directive 2010/63/EU/References/Index