{"title":"Farmacologia","description":null,"products":[{"product_id":"non-peptide-inhibitors-of-proprotein-convertase-subtilisin-kexins-pcsks","title":"Non-peptide Inhibitors of Proprotein Convertase Subtilisin Kexins (PCSKs)","description":"\u003cp\u003eThe Ca+2-dependent mammalian Proprotein Convertase Subtilisin Kexins (PCSKs) or Proprotein\/ Prohormone Convertases (PCs) are a family of endoproteases that play critical roles not only in normal development and metabolism but also in various physiological and pathological conditions. These were initiated by the proteolytic processing of large inactive proproteins into their shorter bioactive mature forms by the PCSK enzymes. These events take place in a highly selective, orchestrated, and stepwise manner. Among the various proprotein substrates of PCSK enzymes, particularly important are the precursor growth factors that include proPDGF-A, B, proIGF-1, 2 and proVEGF-C because of their strong implications in neoplasia initiation, progression, and metastasis. As a result of these findings, PCSK enzymes, particularly furin or PCSK3, became a major target for possible interventions of cancer via the use of their selective inhibitors. Significant progress has been accomplished in the development of peptide and protein-based PCSK inhibitors. However, non-peptide PCSK9 inhibitors are more preferable because of their drug-like and other characteristics. So far, a few non-peptide inhibitors of PCSK enzymes of various types of chemical structures have been described in the literature. These include (i) Carbocyclic compounds of diterpene and streptamine class. (ii) Nitrogen (N)-based heterocyclic compounds of various types and chemical structures such as (a) pyrrolidine bis piperazines, (b) Cu\/Zn chelating terpyridine derivatives; (iii) Oxygen (O)-based Heterocyclic compounds of varying types of chemical structures such as (a) Flavonoids, (b) Coumarins of simple and dimeric types, (c) Quinonoids, (d) Iridoids; (iv) Aromatic compounds such as (a) Aryl guanidino and amidino derivatives, (b) Naphthyl fluorescein derivative, and (c) Phenyl Arsonic acids; and (v) C2-symmetrical aromatic azo-compounds. When measured against a small peptidyl-MCA fluorogenic substrate, these inhibitor\u003c\/p\u003e","brand":"Morgan and Claypool Publishers","offers":[{"title":"Default Title","offer_id":52651442471279,"sku":"9781615044740","price":286.98,"currency_code":"BRL","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0921\/9384\/9711\/files\/1615044744.jpg?v=1770674361"},{"product_id":"pathophysiology-and-pharmacology-in-nursing","title":"Pathophysiology and Pharmacology in Nursing","description":"\u003cp\u003ePathophysiology and Pharmacology in Nursing\u003c\/p\u003e","brand":"Sage Publications","offers":[{"title":"Default Title","offer_id":52657163207023,"sku":"9781526432117","price":267.34,"currency_code":"BRL","in_stock":true}]},{"product_id":"the-essential-guide-to-psychiatric-drugs","title":"The Essential Guide to Psychiatric Drugs","description":"\u003cp\u003eThe Essential Guide to Psychiatric Drugs\u003c\/p\u003e","brand":"St. Martins Press-3PL","offers":[{"title":"Default Title","offer_id":52657690575215,"sku":"9780312368791","price":177.85,"currency_code":"BRL","in_stock":true}]},{"product_id":"medication-madness","title":"Medication Madness","description":"\u003cp\u003eMedication Madness\u003c\/p\u003e","brand":"St. Martins Press-3PL","offers":[{"title":"Default Title","offer_id":52657692442991,"sku":"9780312565503","price":159.34,"currency_code":"BRL","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0921\/9384\/9711\/files\/031256550X.jpg?v=1770818479"},{"product_id":"the-psychopharmacology-of-smoking","title":"The Psychopharmacology of Smoking","description":"\u003cp\u003eThe Psychopharmacology of Smoking\u003c\/p\u003e","brand":"Cambridge University Press","offers":[{"title":"Default Title","offer_id":53193517924719,"sku":"9780521105903","price":332.74,"currency_code":"BRL","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0921\/9384\/9711\/files\/0521105900.jpg?v=1783705830"},{"product_id":"a-practical-approach-to-toxicological-investigations","title":"A Practical Approach to Toxicological Investigations","description":"\u003cp\u003eA Practical Approach to Toxicological Investigations\u003c\/p\u003e","brand":"Cambridge University Press","offers":[{"title":"Default Title","offer_id":53193525166447,"sku":"9780521105460","price":325.87,"currency_code":"BRL","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0921\/9384\/9711\/files\/0521105463.jpg?v=1783706515"},{"product_id":"advances-in-material-design-for-regenerative-medicine-drug-delivery-and-targeting-imaging","title":"Advances in Material Design for Regenerative Medicine, Drug Delivery and Targeting\/Imaging","description":"\u003cp\u003eAdvances in Material Design for Regenerative Medicine, Drug Delivery and Targeting\/Imaging\u003c\/p\u003e","brand":"Cambridge University Press","offers":[{"title":"Default Title","offer_id":53461432762735,"sku":"9781107408388","price":272.96,"currency_code":"BRL","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0921\/9384\/9711\/files\/1107408385.jpg?v=1789151385"},{"product_id":"the-benzodiazepine-receptor","title":"The Benzodiazepine Receptor","description":"\u003cp\u003eThe Benzodiazepine Receptor\u003c\/p\u003e","brand":"Cambridge University Press","offers":[{"title":"Default Title","offer_id":53480061141359,"sku":"9780521115278","price":357.71,"currency_code":"BRL","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0921\/9384\/9711\/files\/0521115272.jpg?v=1789507464"},{"product_id":"progress-in-neurotherapeutics-and-neuropsychopharmacology","title":"Progress in Neurotherapeutics and Neuropsychopharmacology","description":"\u003cp\u003eProgress in Neurotherapeutics and Neuropsychopharmacology\u003c\/p\u003e","brand":"Cambridge University Press","offers":[{"title":"Default Title","offer_id":53480061469039,"sku":"9780521115612","price":320.04,"currency_code":"BRL","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0921\/9384\/9711\/files\/0521115612.jpg?v=1789507534"},{"product_id":"magnesium","title":"Magnesium","description":"\u003cp\u003eA Medical Game Changer!\u003cbr\u003e\u003cbr\u003eThe painstaking work of digging through every nugget of recent medical research on magnesium revealed a grand picture that even the medical visionary Thomas Levy didn’t anticipate. The bottom line is that magnesium is the natural antidote for the root cause of all pathological damage from every disease and poisoning known to man. As grandiose as that claim may sound, the proof’s inside!\u003cbr\u003e\u003cbr\u003eYes, all the good things you’ve heard about magnesium are true... but there’s so much more! Discover not only the what, but the why and how in this definitive work on magnesium. If you’re a layperson, it will change the way you address your personal health needs. And, if you’re a health practitioner, it will give you tools to effectively treat everything from Alzheimer’s to the Zika virus.\u003cbr\u003e\u003cbr\u003eMagnesium: Reversing Disease contains enough documentation to pass medical muster for the hardcore\u003cbr\u003e\u003cbr\u003eresearcher and yet clear enough that any interested student can appreciate the concepts and applications.\u003c\/p\u003e","brand":"Medfox Publishing","offers":[{"title":"Default Title","offer_id":53480150696303,"sku":"9780998312408","price":167.29,"currency_code":"BRL","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0921\/9384\/9711\/files\/0998312401.jpg?v=1789513019"},{"product_id":"the-story-of-taxol","title":"The Story of Taxol","description":"\u003cp\u003eThe Story of Taxol\u003c\/p\u003e","brand":"Cambridge University Press","offers":[{"title":"Default Title","offer_id":53484777079151,"sku":"9780521032506","price":364.23,"currency_code":"BRL","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0921\/9384\/9711\/files\/0521032504.jpg?v=1789595410"},{"product_id":"ulfaz-udwiyeh-or-the-materia-medica","title":"Ulfaz Udwiyeh, or the Materia Medica","description":"\u003cp\u003eUlfaz Udwiyeh, or the Materia Medica\u003c\/p\u003e","brand":"Cambridge University Press","offers":[{"title":"Default Title","offer_id":53490060591471,"sku":"9781108056090","price":222.46,"currency_code":"BRL","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0921\/9384\/9711\/files\/1108056091.jpg?v=1789686525"},{"product_id":"stahls-illustrated-mood-stabilizers","title":"Stahl's Illustrated Mood Stabilizers","description":"\u003cp\u003eStahl's Illustrated Mood Stabilizers\u003c\/p\u003e","brand":"Cambridge University Press","offers":[{"title":"Default Title","offer_id":53494213771631,"sku":"9780521758499","price":334.16,"currency_code":"BRL","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0921\/9384\/9711\/files\/0521758491.jpg?v=1789750304"},{"product_id":"chemotherapy","title":"Chemotherapy","description":"\u003cp\u003eChemotherapy\u003c\/p\u003e","brand":"Cambridge University Press","offers":[{"title":"Default Title","offer_id":53495164207471,"sku":"9781107644656","price":100.05,"currency_code":"BRL","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0921\/9384\/9711\/files\/1107644658.jpg?v=1789797038"},{"product_id":"histoire-naturelle-des-drogues-simples","title":"Histoire Naturelle Des Drogues Simples","description":"\u003cp\u003eHistoire Naturelle Des Drogues Simples\u003c\/p\u003e","brand":"Cambridge University Press","offers":[{"title":"Default Title","offer_id":53497162662255,"sku":"9781108069199","price":339.59,"currency_code":"BRL","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0921\/9384\/9711\/files\/1108069193.jpg?v=1789816889"},{"product_id":"pharmacologia","title":"Pharmacologia","description":"\u003cp\u003ePharmacologia\u003c\/p\u003e","brand":"Cambridge University Press","offers":[{"title":"Default Title","offer_id":53497176392047,"sku":"9781108069847","price":359.07,"currency_code":"BRL","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0921\/9384\/9711\/files\/1108069843.jpg?v=1789817190"},{"product_id":"historical-sketch-of-the-progress-of-pharmacy-in-great-britain","title":"Historical Sketch of the Progress of Pharmacy in Great Britain","description":"\u003cp\u003eHistorical Sketch of the Progress of Pharmacy in Great Britain\u003c\/p\u003e","brand":"Cambridge University Press","offers":[{"title":"Default Title","offer_id":53497215549807,"sku":"9781108070027","price":340.04,"currency_code":"BRL","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0921\/9384\/9711\/files\/1108070027.jpg?v=1789818017"},{"product_id":"ethnicity-in-drug-development-and-therapeutics","title":"Ethnicity in Drug Development and Therapeutics","description":"\u003cp\u003eEthnicity in Drug Development and Therapeutics\u003c\/p\u003e","brand":"Cambridge University Press","offers":[{"title":"Default Title","offer_id":53500102639983,"sku":"9780521292528","price":344.92,"currency_code":"BRL","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0921\/9384\/9711\/files\/0521292522.jpg?v=1789861990"},{"product_id":"ethno-psychopharmacology","title":"Ethno-Psychopharmacology","description":"\u003cp\u003eEthno-Psychopharmacology\u003c\/p\u003e","brand":"Cambridge University Press","offers":[{"title":"Default Title","offer_id":53501196501359,"sku":"9781107412699","price":329.87,"currency_code":"BRL","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0921\/9384\/9711\/files\/1107412692.jpg?v=1789896323"},{"product_id":"bioinformatics-and-computational-biology-in-drug-discovery-and-development","title":"Bioinformatics and Computational Biology in Drug Discovery and Development","description":"\u003cp\u003eBioinformatics and Computational Biology in Drug Discovery and Development\u003c\/p\u003e","brand":"Cambridge University Press","offers":[{"title":"Default Title","offer_id":53501465985391,"sku":"9781108461153","price":304.03,"currency_code":"BRL","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0921\/9384\/9711\/files\/1108461158.jpg?v=1789904155"},{"product_id":"chemotherapeutic-targets-in-parasites","title":"Chemotherapeutic Targets in Parasites","description":"\u003cp\u003eChemotherapeutic Targets in Parasites\u003c\/p\u003e","brand":"Cambridge University Press","offers":[{"title":"Default Title","offer_id":53502367564143,"sku":"9780521018364","price":330.15,"currency_code":"BRL","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0921\/9384\/9711\/files\/0521018366.jpg?v=1789921486"},{"product_id":"aspects-of-psychopharmacology","title":"Aspects of Psychopharmacology","description":"\u003cp\u003eThe study of drug effects on behaviour and psychological processes has a long history. Developments in the decade prior to first publication had been based on a more adequate synthesis than hitherto of psychology and pharmacology, and as a result great progress was made in establishing psychopharmacology as an interdisciplinary subject in its own right. Undergraduate courses in departments of psychology and pharmacology were increasingly including some coverage of this material, but there was a paucity of texts suitable at this level at the time.\u003c\/p\u003e\n\u003cp\u003eOriginally published in 1984, this book was designed to provide broad coverage of psychopharmacology, with the minimum necessary focus on basic pharmacology and with carefully chosen subjects which are still likely to be of interest to psychology undergraduates and in which good empirical work is available for discussion at that level. The emphasis throughout the book is on the needs of psychology students, but the contents will also interest pharmacology students.\u003c\/p\u003e","brand":"Taylor \u0026 Francis Ltd","offers":[{"title":"Default Title","offer_id":53516591038831,"sku":"9781138691131","price":440.27,"currency_code":"BRL","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0921\/9384\/9711\/files\/1138691135.jpg?v=1790090318"},{"product_id":"generation-rx","title":"Generation RX","description":"\u003cp\u003eGeneration RX\u003c\/p\u003e","brand":"HarperCollins","offers":[{"title":"Default Title","offer_id":67586825159023,"sku":"9780618773565","price":121.28,"currency_code":"BRL","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0921\/9384\/9711\/files\/0618773568.jpg?v=1790441945"},{"product_id":"the-psychopharmacology-of-herbal-medicine","title":"The Psychopharmacology of Herbal Medicine","description":"\u003cp\u003eThe Psychopharmacology of Herbal Medicine\u003c\/p\u003e","brand":"Random House","offers":[{"title":"Default Title","offer_id":67586939519343,"sku":"9780262692656","price":310.51,"currency_code":"BRL","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0921\/9384\/9711\/files\/0262692651.jpg?v=1790444099"},{"product_id":"farmacology","title":"Farmacology","description":"\u003cp\u003eFarmacology\u003c\/p\u003e","brand":"HarperCollins","offers":[{"title":"Default Title","offer_id":67603166593391,"sku":"9780062103154","price":118.55,"currency_code":"BRL","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0921\/9384\/9711\/files\/0062103156.jpg?v=1790567405"},{"product_id":"the-caffeine-advantage","title":"The Caffeine Advantage","description":"\u003cp\u003eThe Caffeine Advantage\u003c\/p\u003e","brand":"Simon \u0026 Schuster","offers":[{"title":"Default Title","offer_id":67621383930223,"sku":"9780743228978","price":131.03,"currency_code":"BRL","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0921\/9384\/9711\/files\/0743228979.jpg?v=1790738390"},{"product_id":"psychopharmacology","title":"Psychopharmacology","description":"\u003cem\u003ePsychopharmacology: A Concise Overview, 3rd Edition \u003c\/em\u003eis an evidence-based overview of the major classes of psychiatric medications and their use in clinical practice. Clinical considerations as to when, why, and how to use each individual medication are discussed in depth, as are relevant clinical controversies and treatment caveats. Each chapter also features an updated table of individual medications and their generic and brand names, dosing information, pertinent clinical comments, black box warnings, and Food and Drug Administration indications. This overview will equip readers with an essential framework of the concepts of psychopharmacology in an accessible length and style ideal for use as either a primer or refresher text. Medical students, residents, practicing physicians, nurse practitioners and other prescribers, as well as non-prescribing mental health clinicians who need to have a functional familiarity with available pharmacotherapies, will benefit from reading this concise book.\u003cbr\u003e","brand":"Oxford University Press","offers":[{"title":"Default Title","offer_id":67651907715439,"sku":"9780197537046","price":478.78,"currency_code":"BRL","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0921\/9384\/9711\/files\/0197537049.jpg?v=1790963045"},{"product_id":"cafers-antipsychotics","title":"Cafer's Antipsychotics","description":"\u003cp\u003e\u003cem\u003eCafer's Antipsychotics\u003c\/em\u003e is an essential resource for any prescriber of psychiatric medication. Filled with pictures, this book makes complex concepts easy to understand and provides tools for remembering more than you thought possible.\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003eTo help you match trade names with generic names of 40 medications, this book features mascots akin to the Xyzal \"Wise Owl\" and Myrbetriq Bladder characters.\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003eEach medication's mascot is incorporated into a visual-mnemonic framework designed for recollection of pharmacokinetic interactions. For instance, CYP2C19 substrates are represented as flowers with CYP2C19 inhibitors as watering cans to make the flowers grow. CYP1A2 substrates are trees to be chopped down by axes (CYP1A2 inducers). \u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003eIn addition to antipsychotics, this book features medications used for treatment of antipsychotic-induced side effects, including dopamine-depleting agents and anticholinergics.\u003c\/p\u003e","brand":"CaferMed LLC","offers":[{"title":"Default Title","offer_id":67654236832111,"sku":"9781735090115","price":197.98,"currency_code":"BRL","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0921\/9384\/9711\/files\/1735090115.jpg?v=1790979160"},{"product_id":"cafers-mood-stabilizers-and-antiepileptics","title":"Cafer's Mood Stabilizers and Antiepileptics","description":"\u003cp\u003e\u003cspan style=\"background-color: transparent;\"\u003eCafer's Psychopharmacology is an essential series for any prescriber of psychiatric medication. Filled with pictures, this book makes complex concepts easy to understand and provides tools for remembering more than you thought possible. \u003c\/span\u003e\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003e\u003cspan style=\"background-color: transparent;\"\u003eTo help you match trade names with generic names of 39 medications, this book features mascots akin to the Xyzal \"Wise Owl\" and Myrbetriq Bladder characters. Each medication's mascot is incorporated into a visual-mnemonic framework designed for recollection of pharmacokinetic interactions. \u003c\/span\u003e\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003e\u003cspan style=\"background-color: transparent;\"\u003eFor instance, CYP2C19 substrates are represented as flowers with CYP2C19 inhibitors as watering cans to make the flowers grow. CYP1A2 substrates are trees to be chopped down by axes (CYP1A2 inducers). Lithium is a battery and anything that interferes with its renal excretion is depicted as a battery charger. \u003c\/span\u003e\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003e\u003cspan style=\"background-color: transparent;\"\u003eIn addition to lithium, this book includes all of the major antiepileptic drugs (encompassing all of the mood stabilizers other than lithium) and all available benzodiazepines (about half of which are FDA approved for treatment of seizure disorders).\u003c\/span\u003e\u003c\/p\u003e","brand":"CaferMed LLC","offers":[{"title":"Default Title","offer_id":67658850337135,"sku":"9781735090122","price":198.24,"currency_code":"BRL","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0921\/9384\/9711\/files\/1735090123.jpg?v=1791087171"}],"url":"https:\/\/internacional.umlivro.com.br\/collections\/farmacologia.oembed?page=2","provider":"UmLivro Internacional","version":"1.0","type":"link"}